Blood changes in hemolytic anemia under ACTH therapy.

PromPt an(l correlate(l svell with the (lepression of gamma globiulius values, aus obserVIttiOts often reportedl ius the treatment of collagen disease with ACTH.5 The alpha I I globulims fractiots s ’as also somewhat elevate(l so that. the svh’sole picture showed some similarity to that of the (‘ollageul (liseases. T)avidson et. al.4 have treated a case in w’hich there was inversion of tl’se plasma proteins with ACTH ausd achieved a similarly prompt effect. Iti Hanset’s’s above metutiotsedl case, re-examination five months after cessatiois of ACTH therapy reveale(l tuormal blood values, normalized gamma globulins atud no reticulocytosis. However, the Coombs test was persistetstly positive atudl the eryt.hrocyte sediment.atioti rate ss’as considerably elevated. Its another patietst. with a history of severe hemolytic au’semia, which had apparetstly beets stopped! by splenect.omy , there ss’as a very subst.au’stial elevatiots of gamma globulitus together with a strongly positive Coombs test. Ii’s view of these fitsditugs it. seemed of ititerest. to investigate the actious of ACTIT its a (‘ttsC of a(’quired hemolyt.ic atsemia, its which no it’sit.ial elevat.iou’s of gamma globulins could he demonstrated.